![]() The deputy wrote in the report that she and a sergeant walked into Thomas' room, pulled back a white sheet, and heard him gasp for air. The spokesperson said when the Pinellas County Sheriff’s Office arrived at the home in an unincorporated part of the county, the medics left, and a deputy noticed Thomas was breathing. Phebe wipes away a tear during an interview with FOX 13.Ī Clearwater Fire and Rescue spokesperson confirmed to FOX 13 in February that the two medics from Station 47 pronounced Thomas deceased. ![]() Her mother and friend tried to pry her off her dad as she yelled to, "God and to everyone." ![]() Phebe recalled the moment, saying she was screaming. However, one of the medics told Phebe "Well ma’am, that’s the body emptying itself of gases," she stated. "I said, ‘No, he’s not he’s not dead,’" Phebe explained to FOX 13 in February. "In addition, you also failed to reassess the patient even after the patient’s family told you that the patient was still alive," the termination notice said.įROM FEBRUARY 2023: 'He's not dead': Clearwater medics on administrative duty for declaring man who was breathing dead That's when she pleaded with them, saying he was, in fact, still breathing. "I feel like they just wanted a paycheck, just another day … ‘We’ll say, okay, ‘then we’ll throw a sheet over him,’ and that’s what they did," Phebe Max well said.Īccording to Phebe, when two Clearwater Fire and Rescue medics showed up, they checked her father's wrist for a pulse and said he was dead. Paramedics pronounced a Clearwater man dead after he suffered a cardiac arrest, but a Pinellas County deputy noticed he was still breathing and called for backup. 2023: Medics under investigation for declaring living man dead He said they both have years of training that they didn’t follow.įeb. "They missed the basics that they should have accomplished, and that is the lowest level of training as basic life support," Ehlers said.ĭespite having life-saving equipment with them and more on the way, Ehlers said the medics didn’t use any of it. One minute later, the chief said, Pickens "witnessed the patient take at least one breath," shared the information with his partner, but they didn’t take any other action. The medics pronounced Maxwell dead at 10:01:58. They reported Thomas was not breathing, without a pulse, cold to the touch, and "completely unresponsive," according to their termination and dismissal notice. An initial assessment was made, such as checking for a pulse and respirations. She started administering CPR as her mother dialed 911.Īccording to Chief Ehlers, Rivero and Pickens arrived at 10:00:35, and made it to the patient's location at 10:01:49. His daughter, Phebe, found him lying on his bedroom floor unresponsive. Full press conference: Clearwater paramedics fired after declaring living patient deadĬlearwater Fire & Rescue terminated two paramedics who said a man was dead, even though he wasn't.
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![]() Here we find that effects of the major predictor of warfarin dosage, SNP −1639 G>A, follow a general correlation that warfarin 50% inhibitory concentration decreases with cellular level of vitamin K epoxide reductase (VKORC1), suggesting stoichiometric inhibition. Improving the dosage management and antidotal efficacy requires mechanistic understanding. The paper Mishima Eikan et al, 2022: A non-canonical vitamin K cycle is a potent ferroptosis suppressor, was published in Nature on August 3, 2022.Dose control of warfarin is a major complication in anticoagulation therapy and overdose is reversed by the vitamin K antidote. ![]() Zijun Wu, was able to demonstrate that FSP1 can reduce Vitamin K to its hydroquinone form, and that this form of Vitamin K is a potent radical-trapping antioxidant – preventing membrane oxidation and corresponding ferroptotic cell death. Pratt’s laboratory, post-doctoral researcher Dr. Using methods previously developed in Prof. ** Professor Pratt’s group provided the research team with the chemical tools and expertise to show how Vitamin K and FSP1 work together to suppress membrane lipid oxidation. “Thus, new aspects of the role of vitamin K throughout the evolution of life are expected to be unveiled” Dr. In addition, since ferroptosis most likely constitutes one of the oldest types of cell death, the researchers hypothesize that vitamin K might be one of the most ancient types of naturally occurring antioxidants. They will serve as the stepping stone for the development of novel therapeutic strategies for diseases where ferroptosis has been implicated “, Dr. “Our results therefore link the two worlds of ferroptosis research and vitamin K biology. Unraveling the identity of this enzyme solved the last riddle of vitamin K metabolism in blood clotting and elucidated the molecular mechanism of why vitamin K constitutes the antidote for overdosing of warfarin. Since vitamin K is critically involved in blood clotting processes, the team further showed that FSP1 is responsible for the vitamin K-reduction pathway insensitive against warfarin, one of the most commonly prescribed anticoagulants.īreakthrough in understanding vitamin K metabolism In addition, they identified that FSP1 is the enzyme that efficiently reduces vitamin K to vitamin K hydroquinone, thereby driving a novel non-canonical vitamin K cycle. Pratt, co-author and University Research Chair in Free Radical Chemistry at the University of Ottawa**. “The reduced forms of Vitamin K and coenzyme Q10 are not very stable, so our finding that FSP1 can maintain them in their active (reduced) state is key to understanding how they are able to function to maintain cell viability.” explained Derek A. The research team now found that the fully reduced form of vitamin K (i.e., vitamin K hydroquinone) is, like the reduced form of coenzyme Q10, a strong lipophilic antioxidant and prevents ferroptosis by trapping oxygen radicals in lipid bilayers. At the time, the team showed that FSP1 reduced coenzyme Q10 to its hydroquinone, which suppressed ferroptosis. Marcus Conrad already identified an enzyme as a novel and strong inhibitor of ferroptosis: ferroptosis suppressor protein-1, short FSP1. Unraveling the long sought-after vitamin K reducing enzyme FSP1 Eikan Mishima, first author of the study explained. “Surprisingly, we identified that vitamin K, including phylloquinone (vitamin K1) and menaquinone-4 (vitamin K2), is able to efficiently rescue cells and tissues from undergoing ferroptosis” Dr. Marcus Conrad, both from the Institute of Metabolism and Cell Death at Helmholtz Munich, along with collaborators from Tohoku University (Japan), University of Ottawa (Canada) and Technical University of Dresden (Germany), systematically studied a number of naturally occurring vitamins, as well as their derivatives. To identify these new molecules, a team of researchers led by Dr. ![]() Since ferroptosis prevention is considered a highly promising approach for the therapy of many degenerative diseases, new mechanisms and compounds regulating ferroptosis are extensively being explored. Vitamin K is a potent ferroptosis suppressor Thus, the present findings put forward the concept that a vitamin K treatment might be a new powerful tool for treating these ferroptosis-related diseases. During the last years, ferroptosis has been implicated as a driver of Alzheimer’s disease and acute organ injuries among many other diseases. In addition, the team identified FSP1 as the warfarin-insensitive enzyme reducing vitamin K, the identity of which had been postulated but remained unknown for more than half a century. Ferroptosis is a natural form of cell death in which cellular iron plays an important role and which is characterized by the oxidative destruction of cellular membranes. The researchers discovered that the fully reduced form of vitamin K acts as an antioxidant efficiently inhibiting ferroptotic cell death. ![]() Try out the latest evolution of the RORTOS flight system, already appreciated by millions of users around the world: unprecedented graphics, realistic weather conditions and a REPLAY function that lets you review your flight moves.įor an even more thrilling experience, connect two devices online and activate the multi-screen mode. Featuring: Game campaign with training missions and 2 scenarios FLIGHT. Head over to one of the trusted game stores from our price comparison. F18 Carrier Landing Lite reviews, ASO score & analysis on App Store, iOS. Now the latest 7.5.2 Mod is availabe on Moddroid. Free download F18 Carrier Landing v7.5.2 MOD APK at F18 Carrier Landing is a simulation games. WORLDWIDE NAVIGATION and FLIGHT PLAN with 500+ accurate AIRPORTS, DAY&NIGHT CYCLE, weather conditions, AIR SPACES CARTOGRAPHY with over 8,000 WAYPOINTS. 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It lets it’s users to transfer their files by simply dragging and dropping them between two near by devices. We continued in the same direction, using the occasional cairn as a reference. Once you pass the sand hiking you are a little over half way to the Gulch. ![]() Here we got to enjoy some lovely sand hiking for a bit before we reached the sandstone. Our route is the first part of the blue one down to Coyote Gulch and back.Īfter passing the sandstone butte the trail leans East a little bit, but not much. For some reason, someone stuck the thing right in the middle of where the trail should have gone. There are cairns to mark the way when you hit the sandstone and we hugged the left side of this butte as we made our way around it. The trail here is fairly well developed. You head North and stay to the left of a prominent sandstone butte. I wouldn’t get one from Mountainsmith though, I would recommend this medium slope from F-Stop Gear or even the large ICU if that worked better.) To make it work right you need to purchase an internal camera unit (ICU). You really need to check it out, I’ve used it for the past couple of months and it does a fantastic job. ( Oh and before I forget, if you want to backpack and carry camera gear I found the best bag for this, it is the Mountainsmith Tanuck 40L backpack. We parked here, prepped our gear, and using the SWEETEST KNIFE EVER that I just purchased from Amazon, I cut open a Dixie Sweet pomegranate from our yard to begin the trek. 4.3 miles down this dirt road sits a corral and large water tank. I took his word for it with a great deal of hesitation after he threw in phrases like “some people used a rope,” and “there were a few people who froze up.”Īfter 36.2 miles on Hole-in-the-Rock Road, we took a left onto 40 Mile Ridge Road (don’t be confused when you see 50 Mile Ridge Road on the right, prior to 40 Mile Ridge Road). He made it sound like it was a casual stroll down to the water’s edge. This way was much shorter than any other access to the gulch, and super simple he said. So this had been Brett’s day for planning, he had decided that we should hit Coyote Gulch via the Sneaker Route. ![]() Not only that, but he has a serious case of “Drive on the Opposite Side of the Road Syndrome.” As of the writing of this post we are working on an intervention for him. Brett pretty much aims for the washboard sections any time he can. We spent the next hour or so loosening our insides thanks to the washboard nature of these high-traffic dirt roads. We headed South on highway 12 for 21 miles or so the the Hole-in-the-Rock Road. It was a super cool place that could only be accessed by driving through a running creek. We had spent the night in a fantastic, secluded cabin, courtesy of Mike & Kelly Anderson. Coyote Gulch via the Moki Steps aka the Sneaker Routeįriday morning in late October we left Boulder, UT around 10 am. ![]() Brookdaleīased on the famous Darlington track, this oval is slightly tighter at one end compared to the other. It takes a while to learn this track but, once you do, it’s very rewarding. Its flat profile is quite deceptive, with some corners carrying enough banking to make any car feel like it’s on an oval. ![]() It’s still the same beast as we’ve all come to know and love, though! Botniaringīotniaring is a bit of a hidden gem of a track. You have a 2014 version available to you in this title, courtesy of former developers ISI. BathurstĪustralia’s most famous track is here in all of its glory. It’s a lovely little club circuit, something that comes up a lot on this list. ![]() Mores is an entertaining short circuit, which makes the most of the terrain around it to create an awesome short circuit. There’s also a similarly challenging karting circuit if you want to try your hands at karting while you’re there. Get ready to push any car to its absolute limit around here. This track is a lot of fun with challenging corners made even more challenging by camber and gradient. You have a fast superspeedway oval, a tricky and flat interior road course, and a “roval” that uses about half of each. Apple Valley Speedwayīased off of Auto Club in Fontana, you have three layouts at your disposal for this track. It takes a lot of guts and a bit more than talent to master your racecraft around this track. This is a very technical track with a figure-eight layout and a lot of camber in the corners. Alaharma – Available as KartSim Alaharma or as a part of KartSim Esports Pack To succeed, you need to be able to make the most of your sliding and bouncing around the kerbs. 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